IDSP110 Biochemistry and Molecular and Cell Biology (3 credits)
This course provides an introduction to the basic biochemical properties of amino acids and proteins, protein assembly and folding into the three-dimensional structures required for function, and an introduction to basic principles of enzyme kinetics, examples of enzyme active site structure and mechanism of action. Membrane transport, carbohydrates and the biochemical processes and enzymes that cells utilize to generate metabolic energy are also included. The course concludes with a basic introduction to nucleic acid structure and function: replication, transcription, RNA processing and protein synthesis.
IDSP113 Genetics (1 credit)
Through lectures and discussions of the current literature, this course will provide the student with an overview of classical genetics as well as an in-depth consideration of several fundamental processes involving DNA, including its recombination and repair. The course will also explore the emerging areas of genomics and proteomics.
IDSP116 Methods in Biomedical Sciences: Biochemical and Molecular Methods (1 credit)
This course covers principles and application of common methods used for separation, detection and analysis of macromolecules and their structure, function, and interaction. The goals of the course are to develop an understanding of basic methods applied to the study of proteins and nucleic acids, to become familiar with the instrumentation used for these methods and to become aware of the ways that these methods and techniques are applied to biomedical study.
IDSP117 Methods in Biomedical Sciences: Recombinant DNA and Cell Biology (1 credit)
Goals are the same as for IDSP116. This course covers recombinant DNA methods, including cloning and gene expression, DNA sequencing, PCR, and mutagenesis. The course also covers analysis of nucleic acids and proteins, including interaction detection methods, genomics and proteomics, direct observation methods of analysis, and immunological methods.
IDSP118 Cell Biology (3 credits)
An introduction to cellular signaling processes in eukaryotic cells, cellular structure, and the mechanisms underlying cell division and protein trafficking. Lectures and discussions of the current literature will cover the cell biology of the nucleus, regulation of the cytoskeleton, secretory pathways, endocytosis, protein targeting, ubiquitin-mediated proteolysis, apoptotic mechanisms, mechanisms of cell division and cell cycle control, protein and membrane trafficking mechanisms, and adhesion-mediated biology.
IDSP119 Gene Expression (1 credit)
Through lectures and discussions of the current literature, this course will provide the student with an overview of fundamental processes of transcription, translation and transposition in prokaryotes and eukaryotes. The course will also explore the roles of siRNA and alternative splicing, and model systems of eukaryotic gene expression.
BCH 224 Biochemistry of Metabolism (2 credits)
Lectures covering generation of metabolic energy and products in animals. Students will learn metabolic pathways and connections between them, as well as their regulation in the context of cells and organisms.
IDSP 226 Basic Biostatistics (1 credit)
This course is designed for graduate students who have little background in statistics. Lectures and associated assignments will provide working knowledge of basic statistical methods and their applications. Topics will include frequency distribution, correlations, regression analysis, probability, distributions and hypothesis testing. Examples of use of these methods, descriptions of experimental design incorporating these methods and ethical treatment of data will be considered.
IDSP 227 Advanced Biostatistics
Topics will include power analysis, parametric and non-parametric analysis, analysis of variance and components and factor analyses. Examples of use of these methods, descriptions of experimental design incorporating these methods and ethical treatment of data will be considered in all aspects of the course.
