Manikandan Panchatcharam, PhD
Associate Professor of Cellular Biology and Anatomy
Master of Science, Biochemistry - University of Madras
PhD, Biochemistry and Biotechnology - University of Madras
Post-Doctoral Fellow - University of North Carolina and University of Kentucky
FAHA – American Heart Association
MBA - Louisiana State University Shreveport
PGDCA - Loyola Institute of Business Administration
News
Congratulations to Drs. Panchatcharam, Miriyala, and Sun! Dr. Manikandan Panchatcharam (PI) and his co-investigators, Drs. Sumitra Miriyala and Hong Sun, were recently awarded an R21 for the NIH grant entitled " Alcohol mediated myocardial lysophosphatidic acid signaling" from the National Institute of Alcohol Abuse and Alcoholism.
Sushmita Bhattarai was awarded as second place in Junior Poster Presentation at Graduate Research day, “Autotaxin-LPA-LPP3 axis regulates mitochondrial respiration in cardiomyocytes” LSU Health Shreveport in 2019.
Utsab Subedi presented “Regulation of lysolipid Signaling by lipid phosphate Phosphatase in vascular injury" moderated poster at industry day held at LSU Health Shreveport on October 11, 2019.
Hosne Ara presented “ATX-LPA-LPP3 axis regulates mitochondrial respiration to limit myocardial dysfunction” moderated poster at industry day held at LSU Health Shreveport on October 11, 2019.
Alcohol-induced Ppap2b suppression in brain endothelial cells leads to blood-brain barrier dysfunction. Special award from the American Physiological Society (3rd place) - Intel International Science and Engineering Fair – 2018 awarded to Grace Sun
Alcohol-induced Ppap2b suppression in brain endothelial cells leads to blood-brain barrier dysfunction. Fourth place in Intel International Science and Engineering Fair in Biochemistry- 2018 awarded to Grace Sun
Alcohol-induced Ppap2b suppression in brain endothelial cells leads to blood-brain barrier dysfunction. Top Scoring Louisiana Finalists at the National Symposium Research Competition - 2018 awarded to Grace Sun
Alcohol-induced Ppap2b suppression in brain endothelial cells leads to blood-brain barrier dysfunction. State award at Louisiana State University –Shreveport Scholars Symposium – 2018 awarded to Grace Sun
Alcohol-induced Ppap2b suppression in brain endothelial cells leads to blood-brain barrier dysfunction. Poster presentation in National Junior Science and Humanities Symposium (JSHS) -2018
Dose-dependent influences of acute and chronic alcohol consumption on the blood-brain barrier. Finalist in International Science and Engineering Fair (ISEF)-2019 awarded to Grace Sun.
Dose-dependent influences of acute and chronic alcohol consumption on the blood-brain barrier. Society for Science and the Public Community Innovation Award -2019 awarded to Grace Sun.
Dose-dependent influences of acute and chronic alcohol consumption on the blood-brain barrier. Third place in Society of Toxicology South Central Chapter Annual Meeting -2019 awarded to Grace Sun.
Panchatcharam M, Eghtesadi NK, Chandra M, Colvin JC, Li C, Sun GK, Escalante-Alcalde D, Nam H, and Miriyala S. Autotaxin-LPA-LPP3 axis on the blood-brain barrier following acute and chronic alcohol consumption. Gordon Research Conference 2019, Alcohol-Induced End Organ Diseases 04/2019 CA.
Sun G., Kevil C, Bhuiyan MS, McCarthy KJ, Miriyala S and Panchatcharam M. Dose-dependent influences of acute and chronic alcohol consumption on the blood-brain barrier: Gulf Coast Vascular Research Consortium, August 27, 2019, Houston, Texas.
Patel F, Sharma S, Bhattarai S, Ara H., Sampognaro G, Colvin JC, Bhuiyan MS, Escalante-Alcalde D, Hui DY, Panchatcharam M and Miriyala S. LPP3 Deficiency Enhances LPA Mediated Signaling and Impairs Mitochondrial Function. Louisiana Biomedical Research Network (LBRN), July 26 , 2019, Louisiana
Nguyen H, Sharma S, Bhattarai S, Ara H., Sampognaro G, Colvin JC, Bhuiyan MS, Escalante-Alcalde D, Hui DY, Miriyala S and Panchatcharam M. Role of Autotaxin-LPA-LPP3 axis in post-ischemic blood-brain barrier disruption. Louisiana Biomedical Research Network (LBRN), July 26 , 2019, Baton Rouge, Louisiana
Alcohol-induced LPP3 suppression in brain endothelial cells leads to blood-brain barrier dysfunction. Experimental Biology – 2019 awarded to Ezar U Bess.
Dose-dependent influences of acute and chronic alcohol consumption on the blood-brain barrier. Second place in Medical & Health Sciences, Louisiana Junior Science and Humanities Symposium (JSHS) -2020 awarded to Grace Sun.
Dose-dependent influences of acute and chronic alcohol consumption on the blood-brain barrier. Oral presentation, third place in Medical & Health Sciences, National Junior Science and Humanities Symposium (JSHS) -2020 awarded to Grace Sun.
Dr. Panchatcharam’s lab publication entitled “Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure” in Redox biology was awarded as a Scientific Research Impact in Basic science in 2020 Research celebration in LSU Health Shreveport.
Research
Dr. Panchatcharam’s research focuses on lipids which play a major factor in blocking blood vessels leading to heart attack and stroke. Among those major lipids, Lysophosphatidic acid (LPA) is been regulated and controlled by Lipid Phosphate Phosphatases (LPPs) which plays a pivotal role. His laboratory focuses on the role of LPA-LPP axis involved in cardiovascular function. He is a PI and Co-Investigator on NIH R15, AAA, AHA, R01, R21 and COBRE grants at LSU Health Shreveport.
Ongoing Research Support:
- 1.R15HL141998-01 Miriyala (PI) Panchatcharam (Co-investigator) NIH/NHLBI
04/2018 - 03/2021
Prenatal ethanol exposure alters lipid metabolism and cerebral microcirculation. These studies' goal is to examine prenatal exposure of alcohol on lipid metabolism and cerebral microcirculation. - 2.R21AA025744-01A1 Panchatcharam (PI), NIH/NIAAA
9/2017- 8/2021
Alcohol-LPP3 axis in ischemic stroke
These studies' goal is to examine the influence of chronic alcohol consumption on brain LPP3 axis in ischemic stroke. - R21AA025744-02S1 Panchatcharam (PI), NIH/NIA
09/2018-08/2021
Alcohol-autotaxin-LPP3 axis in Alzheimer disease risk
These studies' goal is to examine the influence of chronic alcohol consumption on brain autotaxin- LPP3 axis in Alzheimer disease. - AA023610-01A1 Sun (PI), Panchatcharam (Co-investigator)NIH/NIAAA
03/2016 - 02/2021
Light Alcohol Consumption and Ischemic Stroke
These studies' goal is to examine the influence of light alcohol consumption on brain injury following cerebral ischemia in adult rats/mice. - 5.P20GM121307-01A1 Kevil (PI), Panchatcharam (Project leader) NIH/NIGMS
02/2018 - 01/2023
Lysolipid in heart failure development and progression - R15HL141998-01S1 Miriyala (PI), Panchatcharam (Co-investigator)NIH/NIA
12/2019-11/2020
Alcohol-autotaxin-LPP3 axis in Alzheimer disease risk
These studies' goal is to examine the influence of chronic alcohol consumption on brain autotaxin- LPP3 axis in Alzheimer disease. - R21AA026708-01A1 Panchatcharam (PI), NIH/NIAAA
05/2020- 04/2022
Alcohol mediated myocardial lysophosphatidic acid signaling
These studies' goal is to examine the influence of chronic alcohol consumption on heart LPP3 axis in ischemic heart.
Completed Research Support:
- 10SDG4190036 (National Scientist Development Grant -American Heart Association)
M Panchatcharam (PI)
07/01/10 - 06/30/15
Regulation of vascular cells and the arterial response to injury by LPP3. - Diabetes Research and Action Education Foundation grant
M Panchatcharam (PI)
01/01/13 - 06/30/14.
Multidrug resistance protein-1 (MRP-1) as an essential regulator of vascular inflammation and diabetic restenosis. - UL1RR033173 (National Institutes of Health - National Center for Research Resources)
M Panchatcharam (PI)
12/09/11 – 12/31/2012.
Functional validation of PPAP2B as a novel risk for coronary artery disease. - 09BGIA2320011 (Beginning Grant in Aid - American Heart Association- Regional)
M Panchatcharam (PI)
07/01/09 - 06/30/11.
Regulation of vascular cells and the arterial response to injury by LPP3. - AAA-FGAP-5148 American Association of Anatomists - Fellows Grant Award (AAA-FGAP).
M Panchatcharam (Co-Investigator)
01/2018 - 12/2018
Doxorubicin alters myocardial lipid metabolism (Sumitra Miriyala – PI)
International Patents:
- A process for the preparation of alkaline protease. CLRI-NCL Joint patent.
Application No.10/095428, (March 13th, 2002,- 6 Claims), US Patent No. 6777219 B2 - A process for the preparation of alkaline protease. CLRI-NCL Joint patent.
Application No.10/820868 (April 9th, 2004, - 15 Claims). US Patent No. 7186546 B2 - A process for the preparation of alkaline protease and its eco-friendly application in the pre-tanning process of leather manufacture. CLRI-NCL Joint patent.
Indian patent application No.159 DEL 2002
Publications
Selected Publications
- Sumitra M, Manikandan P, Suguna L, Gopalan C. Study of dermal wound healing activity of Trigonella foenum graceum seeds in rats. J Clin Biochem Nutr 28:59-67, 2000. http://doi.org/10.3164/jcbn.28.59
- Sumitra M, Manikandan P, Kumar DA, Gayathri C, Arutselvan N, Manohar BM, Puvanakrishnan R. Experimental myocardial necrosis in rats: Role of arjunolic acid on platelet aggregation, coagulation and antioxidant status. Mol Cell Biochem 224:135-142, 2001. (PMID: 11693190)
- Kumar DA, Manikandan P, Sumitra M, Narayana Raju KVS, Gayathri C, Arutselvan N, Puvanakrishnan R. A novel peptide derivative exhibits antiinflammatory and antioxidant activity in adjuvant induced arthritis in rats. Mol Cell Biochem 229: 9-17, 2002. (PMID: 11936851)
- Manikandan P, Sumitra M, Kumar DA, Gayathri C, Arutselvan N, Manohar BM, Puvanakrishnan R. Antioxidant potential of a novel tetrapeptide derivative in isoproterenol induced myocardial necrosis in rats. Pharmacol 65: 104-110, 2002. (PMID: 11937781)
- Ravishankar, Manohar BM, Balachandran C, Sumitra M, Manikandan P, Puvanakrishnan R. Haemato-biochemical alterations and pathological changes in canine pyometra. Indian J Vet Pathol 28: 14-17, 2004. http://krishikosh.egranth.ac.in/handle/1/2057044?mode=full
- Sumitra M$, Manikandan P$, Kuppu Rao KV, Mohammed Nayeem, Manohar BM, Puvanakrishnan R. Cardiorespiratory effects of diazepam-ketamine, xylazine ketamine and thiopentone anesthesia in male Wistar rats - A comparative analysis. Life Sci 75, 1887-1896, 2004. (PMID: 15302232)
- Manikandan P, Sumitra M, Mohammed Nayeem, Manohar BM, Lokanadam B, Vairamuthu S, Subramaniam S, Puvanakrishnan R. Time course studies on the functional evaluation of experimental chronic myocardial infarction in rats. Mol Cell Biochem 267:47-58, 2004. (PMID: 15663185)
- Manikandan P, Sumitra M, Aishwarya S, Manohar BM, Lokanadam B, Puvanakrishnan R. Curcumin modulates free radical quenching in myocardial ischaemia in rats. Int J Biochem Cell Biol. 36,1967-1980, 2004. (PMID: 15203111)
- Sumitra M, Manikandan P, Mohammed Nayeem, Manohar BM, Lokanadam B, Vairamuthu S, Subramaniam S, Puvanakrishnan R Time course studies on the initiation of complement activation in acute myocardial infarction induced by coronary artery ligation in rats. Mol Cell Biochem 268: 149-158, 2005. (PMID: 15724448)
- Sumitra M$, Manikandan P$, Suguna L. Efficacy of Butea monosperma on dermal wound healing in rats. Int J Biochem Cell Biol 37: 566-573, 2005. (PMID: 15618014)
- Panchatcharam M, Sumitra M, Gayathri VS, Suguna. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem. L 290:87-96, 2006. (PMID: 16770527)
- Miriyala S, Panchatcharam M, Rengarajulu P. Cardioprotective effects of curcumin. Adv Exp Med Biol 595:359-377, 2007. (PMID:17569220)
- Smyth SS, Cheng HY, Miriyala S, Panchatcharam M, Morris AJ. Roles of Lysophosphatidic Acid in Cardiovascular Physiology and Disease. Biochim Biophys Acta 1781:563-570, 2008. (PMID: 18586114)
- Pamuklar Z, Lee JS, Cheng HY, Panchatcharam M, Charnigo R, Steinhubl S, Morris AJ, Smyth SS. Individual heterogeneity in platelet responses to lysophosphatidic acid. Arterioscler Thromb Vasc Biol. 28: 555-561, 2008. (PMID: 18202325)
- Panchatcharam M, Miriyala S, Yang F, End C, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular responses but not blood pressure. Circ Res. 103:662-670, 2008. (PMID: 18703779)
- Morris AJ, Panchatcharam M, Cheng HY, Federico L, Fulkerson Z, Selim S, Miriyala S, Escalante-Acalde D, and Smyth SS. Regulation of vascular cell function by bioactive Lysophospholipids. J Thromb Haemostasis, 7: 38-43, 2009.(PMID: 19630765)
- Pamuklar Z, Federico L, Liu S, Umezu-Goto M, Dong A, Panchatcharam M, Fulkerson Z, Berdyshev E, Natarajan V, Fang F, van Meeteren LA, Moolenaar WH, Mills GB, Morris AJ, Smyth SS. Autotaxin/lysophospholipase D and lysophosphatidic acid-regulate murine hemostasis and thrombosis. J Biol Chem, 284:7385-7394, 2009. (PMID: 19139100)
- Sumitra M$, Manikandan P$, Gayathri VS, Mahendran P, Suguna L.. Emblica officinalis exerts wound healing action through upregulation of collagen and extracellular signal-regulated kinases (Erk1/2). Wound Rep Reg, 17: 99-107, 2009.(PMID: 19152656)
- Meredith D$, Panchatcharam M$, Miriyala S, Tsai YS, Morris AJ, Maeda N, Stouffer GA and Smyth SS. Dominant-negative loss of function in PPARγ enhances smooth muscle cell proliferation, migration, and vascular remodeling. Arterioscler Thromb Vasc Biol 29:465- 471, 2009. (PMID: 19179641)
- Miriyala S, Subramanian T, Panchatcharam M, Ren H, Sunkara M. Drenan T, Smyth SS, Spielmann HP and Morris AJ. Functional Characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates. J. Biol. Chem, 285:13918-29, 2010. (PMID: 20110354)
- Panchatcharam M*, Miriyala S, Yang F, Wodnicka MC, Quilliam LA, Anaya P, Morris AJ, and Smyth SS. Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling". Int J Biochem Cell Biol 42(6):965-74, 2010. (PMID: 20184965)
- Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS. Lysophosphatidic Acid Signaling Protects Pulmonary Vasculature From Hypoxia-Induced Remodeling. Arterioscler Thromb Vasc Biol. 32:24-32, 2012. (PMID: 22015657)
- Dong A, Sunkara M, Panchatcharam M, Salous A, Selim S, Morris AJ, Smyth SS. Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury. Adv Hematol 924042, 2012. (PMID: 22919395)
- Miriyala S, Panchatcharam M, Landar A, Ramanujam M, Chatterjee S, Muthuswamy A. The Janus of oxidative stress signaling in different pathophysiological conditions. Oxid Med Cell Longev 708796; 2013. (PMID: 23861992)
- Miriyala S, Panchatcharam M, Ramanujam M and Puvanakrishnan R. A novel tetrapeptide derivative exhibits in vitro inhibition of neutrophil derived reactive oxygen species and lysosomal enzymes release. Oxid Med Cell Longev. 853210; 2013. (PMID: 23819015)
- Ren H, Panchatcharam M, Mueller P, Escalante-Alcalde D, Morris AJ, Smyth SS. Lipid phosphate phosphatase (LPP3) and vascular development. Biochim Biophys Acta. 1831(1):126-32, 2013. (PMID: 22835522)
- Panchatcharam M, Miriyala S, Salous A, Wheeler J, Dong A, Sunkara M, Escalante- Alcalde, Morris AJ, Smyth SS. Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation and limits neointimal hyperplasia. Arterioscler Thromb Vasc Biol.33 (1):52-9, 2013. (PMID: 23104851)
- Salous A, Panchatcharam M, Sunkara M, Morris AJ, Smyth SS. Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice. J Lipid Res 54(10):2775-2784; 2013. (PMID: 23948545)
- Panchatcharam M, Salous A, Miriyala S, Wheeler J, Dong A, Sunkara M, Escalante- Alcalde, Morris AJ, Smyth SS. Mice with targeted inactivation of Ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability. Arterioscler Thromb Vasc Biol 34:837-845; 2014. (PMID: 24504738)
- Miriyala S, Chandra M, Maxey B, Day A, St. Clair DK, Panchatcharam M*. Arjunolic acid ameliorates reactive oxygen species via inhibition of p47phox-serine phosphorylation and mitochondrial dysfunction. Int.J.Cell.Biol and Biochem 68:70-77; 2015. (PMID: 26319153)
- Chandra M, Panchatcharam M, and Miriyala S. Manganese Superoxide Dismutase: Guardian of the Heart. MOJ Anat Physiol 1(2):00006; 2015. (http://medcraveonline.com/MOJAP/MOJAP-01-00006.php)
- Chandra M, Fox J, Miriyala S and Panchatcharam M*. Lipid phosphate phosphatase -3 and Its Role in Mitochondrial Function. MOJ Anat Physiol 2(1):00033; 2016. (http://medcraveonline.com/MOJAP/MOJAP-02-00033.php)
- Fox J, Chandra M, Panchatcharam M, and Miriyala S. Animal Models in Cardiovascular Diseases. MOJ Anat Physiol 2(1):00034; 2016. (http://medcraveonline.com/MOJAP/MOJAP-02-00034.php).
- Miriyala S, Thippakorn C, Chaiswing L, Xu Y, Noel T, Tovmasyan A, Batinic-Haberle I, Vander Kooi CW, Chi W, Abdel Latif A, Panchatcharam M, Prachayasittikul V, Butterfield DA, Vore M, Moscow J, St. Clair DK. Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. Free Radic Biol Med 91:68-80; 2016. (PMID: 26689472)
- Chandra M, Miriyala S, Panchatcharam M. PPARγ and Its Role in Cardiovascular Diseases. PPAR Res 6404638; 2017. (PMID: 28243251)
- Jackson KL, Lin WL, Miriyala S, Dayton RD, Panchatcharam M, McCarthy KJ, Castanedes-Casey M, Dickson DW, Klein RL.p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration. PLoS One 12(1):e0169291; 2017. (PMID: 28076378)
- Sreedhar A, Lefort J, Petruska P, Gu X, Shi R, Miriyala S, Panchatcharam M, Zhao Y. UCP2 upregulation promotes PLCγ-1 signaling during skin cell transformation. Mol Carcinog. 56(10):2290-2300; 2017.(PMID: 28574619)
- Alam S, Abdullah CS, Aishwarya R, Orr AW, Traylor J, Miriyala S, Panchatcharam M, Pattillo CB, Bhuiyan MS. Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes. Biosci Rep 37(4). pii: BSR20170898; 2017. (PMID: 28667101)
- Sreedhar A, Petruska P, Miriyala S, Panchatcharam M, Zhao Y.UCP2 overexpression enhanced glycolysis via activation of PFKFB2 during skin cell transformation. Oncotarget 8(56):95504-95515; 2017.(PMID: 29221144)
- Chandra M, Escalante-Alcalde D, Bhuiyan MS, Orr AW, Kevil CG, Morris AJ, Nam H, Dominic P, McCarthy KJ, Miriyala S*, Panchatcharam M. Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure. Redox Biology 14, 261-271; 2018. (PMID: 28982073). *corresponding author
- Alam S, Abdullah CS, Aishwarya R, Miriyala S, Panchatcharam M, Peretik JM, Orr AW, James J, Robbins J, Bhuiyan MS. Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity. Journal of the American Heart Association. 2018; 7(14). (PMID: 29987122)
- Abdullah CS, Alam S, Aishwarya R, Miriyala S, Panchatcharam M, Bhuiyan MAN, Peretik JM, Orr AW, James J, Osinska H, Robbins J, Lorenz JN, Bhuiyan MS. Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics. Journal of the American Heart Association. 7(20):e009775; 2018. (PMID: 30371279)
- Abdullah CS, Alam S, Aishwarya R, Miriyala S, Bhuiyan MAN, Panchatcharam M, Pattillo CB, Orr AW, Sadoshima J, Hill JA, Bhuiyan MS. Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration. Scientific reports. 9(1):2002; 2019.(PMID: 30765730)
- Aishwarya R, Alam S, Abdullah CS, Morshed M, Nitu SS, Panchatcharam M, Miriyala S, Kevil CG, Bhuiyan MS. Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes. Redox Biol . 2020 Jul 26;36:101660. doi: 10.1016/j.redox.2020.101660 (PMID: 32750667)
- Sharma S, Bhattarai S, Ara H, Sun G, St. Clair DK, Kevil CG, Watts MN, Dominic P, Shimizu T, Bhuiyan MS, McCarthy KJ, Sun H, Panchatcharam M, Miriyala S*. SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy. Redox Biology (in press https://www.sciencedirect.com/science/article/pii/S2213231720309459) (PMID: 33049519) *corresponding author
- Alam S, Abdullah CS, Aishwarya R, Morshed M, Nitu SS, Miriyala S, Panchatcharam M, Kevil CG, Orr AW, Bhuiyan MS. Dysfunctional mitochondrial dynamic and oxidative phosphorylation precedes cardiac dysfunction in R120G-αB-crystallin induced desmin-related cardiomyopathy. Journal of the American Heart Association (Accepted - In Press JAH35669 Article DOI: 10.1161/JAHA.120.017195)
- Abdullah CS, Aishwarya R, Alam S, Morshed M, Remex NS, Nitu SS, Sadia Nitu1, Kolluru GK, Traylor J, Miriyala S, Panchatcharam M, Hartman B, King J, Bhuiyan MAN, Chandran S, Woolard MD, Yu X, Goeders NE, Paari D, Arnold CL, Stokes K, Kevil CG, Orr AW, Bhuiyan MS. Methamphetamine induces cardiomyopathy by Sigmar1 inhibition dependent impairment of mitochondrial dynamics and function . Nature - Communication Biology (COMMSBIO-20-0906-T – Resubmitted - Minor Corrections - Under review)
Complete List of my Published Work in MyBibliography: LEARN MORE
Team
I received an MD degree from Bangladesh. I achieved a PhD from Nagoya University Graduate School of Medicine of Japan, from the Department of Molecular Pathology under the direct supervision of renowned professor Dr. Masahide Takahashi. During my PhD period, my research was focused on the Wnt signaling, which is involved in proliferation and migration of the cells during disease progression, and I found for the first time that Daple is involved in non-canonical Wnt signaling Pathway. I continued as a post-doctoral fellow in the same institute to look at the mTORC1 signaling and microtubule dynamic assembly in cells. After that, I joined as a Research resident in the Department of Molecular Pathology of Aichi cancer center, Nagoya Japan. In 2018, I moved to the USA and joined LSU Health Shreveport as a post-doctoral scholar.
The goal of my current research is to investigate the contribution of lysophosphatidic acid (LPA)-lipid phosphate phosphatase (LPP) mediated Wnt and mTORC1 signaling in hyperglycemic vascular smooth cells (SMC) that mediate the pathogenesis of diabetic restenosis.
I received my MS in Biotechnology from Tribhuvan University, Nepal. I have worked as a research associate for two years in Centre for Molecular Dynamics Nepal (CMDN) in various projects of wild life genetics and public health genetics projects. I joined the LSU Health Shreveport Graduate School in August 2017 as a graduate student.
I am a first year Graduate Student at LSU Health Shreveport. I have received a Bachelor of Physical Therapy from HNB Garghwal University, India and a Master of Public Health from LSU-Shreveport.
My work mainly focuses on the role of hyperglycemia in vascular calcification through the lysophosphatidic acid (LPA) signaling pathway and emphasizes on the role of Lipid phosphate phosphatase 3(LPP3) which mediates enzymatic dephosphorylation of extracellular synthesized LPA minimizing vascular calcium deposition leading to cellular homeostasis.
Positions
Post Doctoral Position
The Panchatcharam Laboratory has an opening for a Post-doctoral fellows. Interested candidates should contact Dr. Mani at mpanch@lsuhsc.edu.
Undergraduate Students
The Panchatcharam Laboratory has an opening for a student-worker position. Interested candidates should contact Dr. Mani at mpanch@lsuhsc.edu.
Contact Us
Contact Us
LSU Health Shreveport
Department of Cellular Biology & Anatomy
1501 Kings Hwy
Shreveport, LA 71103
Email:
mpanch@lsuhsc.edu
Office:
(318) 675-6938