Sadiya Parveen-Nesson, PhD
Assistant Professor of Microbiology and Immunology
Bachelor of Sciences (BSc): Dr RML Avadh University, Uttar Pradesh, India (Industrial Microbiology & Chemistry)
Master of Sciences (MSc): Dr RML Avadh University, Uttar Pradesh, India (Microbiology)
PhD: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India
Postdoctoral Fellowship: Centre for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Research
Our laboratory primarily focuses on understanding how Mycobacterium tuberculosis perturbs host metabolic pathways in both immune and non-immune cell types at the single-cell level
My primary interest is identification and characterization of the immunometabolic pathways driving tuberculous granuloma formation and tuberculosis pathogenesis, using immune-phenotyping, metabolomics, and single-cell RNA sequencing. A better understanding of these processes will lead to the discovery of development of effective clinical tools for tuberculosis treatment.
Project 1: Characterization of the immunometabolic drivers of granuloma formation.
Tuberculosis is a highly complex disease, caused by Mycobacterium tuberculosis (Mtb). The complex interplay of alveolar cells, immune cells, and Mtb drives granuloma formation is schematically diagrammed in the figure. Granulomas are the pathological hallmark of TB and of the host's response to contain Mtb infection. The breakdown of the granuloma leads to the release and dissemination of infectious Mtb. As a result, understanding the precise immunometabolic processes that govern granuloma formation and function is crucial for developing better diagnostic tools, treatments, and vaccines. We are currently utilizing interdisciplinary approaches including microbiology, immunology, single-cell transcriptomics and metabolomics to approach this unique scientific problem.
Reference: Parveen S, Murphy JR, and Bishai WR. (2021). Targeting inhibitory cells such as Tregs and MDSCs in the tuberculous granuloma. Springer Cham. (Book Chapter)
Project 2: Determine the role of bacterial and host glutamine metabolism in TB pathogenesis
Glutamine metabolism upregulation has been associated with several bacterial, viral, and oncogenic diseases, yet its role is poorly understood in TB pathogenesis. While host immune cells may limit Mtb's access to glutamine as part of the immune response, Mtb alters host glutamine metabolism, potentially affecting immune cell function and the overall immune response to infection. My research goal is to understand the precise mechasnim(s) of how the host and mycobacterial glutamine metabolism influences TB pathogenesis. These new findings will have the potential to define unique targets that may result in new approaches to contain TB by either disrupting bacterial nutrient acquisition or improving the functionality of the host immune response.
Reference: Parveen S* and Bishai WR (2024). Role of Glutamine metabolism in tuberculosis pathogenesis: A mini review. Frontiers in Tuberculosis (In Press) (*co-corresponding author) (Review); Parveen S, Shen J, Lun S, Zhao L, Koleske B, Leone RD, Rais R, Powell JD, Murphy JR, Slusher BS, and Bishai WR (2023). Glutamine metabolism has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis. Nature Communications. PMID: 37973991 (Research Article)
Publications
SELECTED PUBLICATIONS
- Parveen S* and Bishai WR (2024). Role of Glutamine metabolism in tuberculosis pathogenesis: A mini review. Frontiers in Tuberculosis (*co-corresponding author) (Review)
- Parveen S, Shen J, Lun S, Zhao L, Koleske B, Leone RD, Rais R, Powell JD, Murphy JR, Slusher BS, and Bishai WR (2023). Glutamine metabolism has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis. Nature Communications. PMID: 37973991
- Ordonez AA, Saupe F, Kasper CA, Turner ML, Parveen S, Flavahan K, Shin H, Artemov D, Ittig SJ, and Jain SK (2023). Imaging Tumor-targeting Bacteria using 18F-Fluorodeoxysorbitol Positron Emission Tomography, Journal of Infectious diseases. PMID: 37788499
- Parveen S, Lun S, Urbanowski ME, Cardin M, Murphy JR, and Bishai WR (2021). Effective host-directed therapy for tuberculosis by targeted depletion of myeloid-derived suppressor cells and related cells using a diphtheria toxin-based fusion protein. Journal of Infectious Diseases. PMID: 33955457
- Parveen S, Siddharth S. Chueng LS, Kumar A, Murphy JR, Sharma D, and Bishai WR (2021). IL-4 receptor targeting as an effective immunotherapy against triple-negative breast cancer. Molecular Oncology. PMID: 33682324
- Krug S, Parveen S*, and Bishai WR (2021). Host-Directed Therapies: Modulating Inflammation to Treat Tuberculosis. Front Immunol. PMID: 33953722 (*co-first author) (Review)
- Parveen S, Murphy JR, and Bishai WR. (2021). Targeting inhibitory cells such as Tregs and MDSCs in the tuberculous granuloma. Springer Cham. (Book Chapter)
- Parveen S., Bishai WR, and Murphy JR. (2019) Corynebacterium diphtheriae: diphtheria toxin, the tox operon and its regulation by Fe2 + -activation of apo-DtxR. Microbiology Spectrum (ASM Press). PMID: 31267892 (Book Chapter)
- Kumar P, Kumar A, Parveen S, Murphy JR, and Bishai WR. (2019). Recent advances with Treg depleting fusion protein toxins for cancer immunotherapy. Immunotherapy. PMID: 31361167 (Review)
- Cheung LS, Fu J, Kumar P, Kumar A, Urbanowski ME, Ihms EA, Parveen S, Bullen CK, Patrick GJ, Harrison R, Murphy JR, Pardoll DM, and Bishai WR (2019). Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti-PD-1 in melanoma. Proceeding of National Academy of Sciences USA. PMID: 30718426
- Kumar A, Parveen S*, Sharma I, Pathak H, Deshmukh M, Sharp JA, and Kumar S. (2019) Structural and mechanistic insights into EchAMP: A antimicrobial protein from the Echidna milk. Biochimica et Biophysica Acta-Biomembranes. PMID: 30951703 (*co-first author)
- Parveen S, and Reddy M. (2017) Identification of YfiH (PgeF) as a factor contributing to the maintenance of bacterial peptidoglycan composition. Molecular Microbiology. PMID: 28612943
- Singh SK, Parveen S, Saisree L, and Reddy M. (2015) Regulated proteolysis of a cross-link specific peptidoglycan hydrolase contributes to bacterial morphogenesis. Proceeding of National Academy of Sciences USA. PMID: 26283368
Inventions/Patents
Positions
Post-doctoral Fellows
We are currently recruiting Post-doctoral Fellows. Please send your CV, cover letter and contact information of three referees to Dr. Parveen at sadiya.parveennesson@lsuhs.edu with the subject line “Application for postdoctoral researcher position”.
Graduate Students
Students interested in working in our Department should visit our Graduate Program.
Undergraduate Students
Our Undergraduate Biomedical Research Fellowship program provides bright undergraduates a chance to gain hands-on research experience through a paid internship. More information can be found at the Undergraduate Fellowship.
contact
Contact Us
LSU Health Shreveport
Department of Microbiology & Immunology
1501 Kings Hwy
Shreveport, LA 71103
Email: sadiya.parveennesson@lsuhs.edu
Office: 318-675-4351