Arteriogenesis is the process that occurs when small caliber arterioles become larger and capable of carrying much more blood flow. This process usually occurs due to increased shear rates in the arterial tree. Our R01 is focused on the effect that glutathione plays on proteins involved in the process of arteriogenesis. Preliminary data suggest that protein glutathionylation may play a role in both the inflammatory and the cellular signaling cascades responsible for artery remodeling.

Luisa Delgadillo

Graduate Assistant
Email: luisa.delgadillo@lsuhs.edu

Teresita Sanchez

Transient
Email: teresita.sanchez@lsuhs.edu

Larsen Jennings

Project: Cancer cell chemotaxis
Currently: A student at LSU, Baton Rouge, LA 

Selected Publications

1. Prasai PK, Shrestha B, Orr AW, Pattillo CB. Decreases in GSH:GSSG activate vascular endothelial growth factor receptor 2 (VEGFR2) in human aortic endothelial cells. Redox Biol. 2018 Oct;19:22-27. doi: 10.1016/j.redox.2018.07.015. Epub 2018 Jul 25. PubMed PMID: 30096614; PubMed Central PMCID: PMC6086407.
2. Shrestha B, Prasai PK, Kaskas AM, Khanna A, Letchuman V, Letchuman S, Alexander JS, Orr AW, Woolard MD, Pattillo CB. Differential arterial and venous endothelial redox responses to oxidative stress. Microcirculation. 2018 Oct;25(7):e12486. doi: 10.1111/micc.12486. Epub 2018 Jul 23. PubMed PMID: 29923664; PubMed Central PMCID: PMC6226026.
3. Kolluru GK, Prasai PK, Kaskas AM, Letchuman V, Pattillo CB. Oxygen tension, H2S, and NO bioavailability: is there an interaction? J Appl Physiol (1985). 2016 Jan 15;120(2):263-70. doi: 10.1152/japplphysiol.00365.2015. Epub 2015 Sep 17. Review. PubMed PMID: 26384410.

Complete List of Publications

May 2019, Boston, MA - The Pattillo Lab attended the 2019 ATVB Vascular Discovery meeting and presented two posters. Dr. Shrestha presented a poster titled "Antioxidant Glutathione Regulation of Pro-angiogenic Immune Factors During Ischemia." Dr. Rashdan presented a poster titled "Glutathione Regulates Arterial Calcification via Altered Matrix Remodeling." Well done everyone!

May 2018, San Francisco, CA - Dr. Shrestha was awarded a travel award for Young Investigators from the ATVB/PVD council at the AHA conference for a second year in a row. Congratulations Bee!

May 2017, Minneapolis, MN - Dr. Shrestha was awarded a travel award for Young Investigators from the ATVB/PVD council at the AHA conference. Congratulations Bee!

Post-doctoral Fellows

While we are not currently recruiting Post-doctoral Fellows, quality candidates will always be considered.  To enquire about opportunities, contact Dr. Pattillo at christopher.pattillo@lsuhs.edu.

Graduate Students

Graduate students interested in conducting research in the Pattillo lab should review the current laboratory research directions and contact Dr. Pattillo at christopher.pattillo@lsuhs.edu.

Undergraduate Research Assistants

We are always looking for motivated undergraduate students who would like to develop scientific laboratory skills. To enquire about opportunities, contact Dr. Pattillo at christopher.pattillo@lsuhs.edu.

Medical Students, Residents, and Fellows

The Pattillo laboratory has a number of research projects available for Medical Students, Residents, and Fellows. Those interested should contact Dr. Pattillo at christopher.pattillo@lsuhs.edu for more information.