Kenneth E. McMartin, PhD, FAACT
Professor of Pharmacology, Toxicology and Neuroscience
Bachelor of Arts - 1973, Coe College, Cedar Rapids, Iowa
PhD - 1977, University of Iowa, Iowa City
Post-doctoral Fellow - Karolinska Institute, Huddinge, Sweden. 1977 - 1979
News
News
MCMARTIN RECEIVES ACCT CAREER ACHIEVEMENT AWARD
September 28, 2023
Dr. McMartin received the Career Achievement Award from the American Academy of Clinical Toxicology (AACT) at the North American Congress of Clinical Toxicology (NACCT) meeting in Montreal, Canada on September 28. In addition to receiving the award, He was invited to give the Career Achievement lecture at the meeting on September 30 with my hour long presentation entitled ” ANECDOTES ON ANTIDOTES: ANALYSES FROM AN ACADEMIC”
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Kenneth E. McMartin, PhD, Professor of Pharmacology, Toxicology & Neuroscience, received the American Academy of Clinical Toxicology Distinguished Service Award at the North American Congress of Clinical Toxicology.
Research
Major Research Interests
Development of antidotes for poisonings, mechanisms of toxicity of alcohols and glycols, renal toxicology, folate metabolism and transport.
Achievements and Awards
1988 Kenneth Morgareidge Award in Toxicology, International Life Sciences Institute
1997/2000 Fomepizole approved for marketing as antidote against ethylene glycol/methanol poisonings
2009 Fellow, American Academy of Clinical Toxicology
2010 Society of Toxicology Translational Impact Award
2016 Member, Board of Scientific Counselors, National Toxicology Program, National Institute for Environmental Sciences (NIEHS)
Publications
Selected Recent Publications
- Besenhofer LM, McLaren MC, Latimer B, Bartels M, Filary MJ, Perala AW, McMartin KE. Role of tissue metabolite accumulation in the renal toxicity of diethylene glycol. Toxicol Sci. 123: 374-83, 2011.
- Besenhofer LM, Cain MC, Dunning C, McMartin KE. Aluminum citrate prevents renal injury from calcium oxalate crystal deposition. J Am Soc Nephrol. 23: 2024-33, 2012.
- Landry GM, Dunning CL, Conrad T, Hitt MJ, McMartin KE. Diglycolic acid Inhibits succinate dehydrogenase activity in human proximal tubule cells leading to mitochondrial dysfunction and cell death. Toxicol Lett. 221:176-84, 2013.
- Landry GM, Dunning CL, Abreo F, Latimer B, Orchard E, McMartin KE. Diethylene glycol-induced toxicities show marked threshold dose response in rats. Toxicol Appl Pharmacol. 282: 244-51, 2015.
- McMartin KE, Jacobsen D, Hovda KE. Antidotes for poisoning by alcohols that form toxic metabolites. Brit J Clin Pharmacol. 81: 505-15, 2016.
- Conrad T, Landry GM, Aw TY, Nichols R, McMartin KE. Diglycolic acid, the toxic metabolite of diethylene glycol, chelates calcium and produces renal mitochondrial dysfunction in vitro. Clin Toxicol. 54: 501-11, 2016.
- Robinson CN, Latimer B, Abreo F, Broussard K, McMartin KE. In-vivo evidence of nephrotoxicity and altered hepatic function in rats following administration of diglycolic acid, a metabolite of diethylene glycol. Clin Toxicol. 55: 96-105, 2017.
Team
Current Lab Members
Julie Dagenhardt, Graduate Student
Effect of diglycolic acid on glutathione homeostasis in cells
Recent Lab Members
Courtney Jamison, (PhD, 2021), currently working as an Associate Toxicologist at WuXi AppTec.
Dissertation: Neurotoxic Effects of Nephrotoxic Compound Diethylene Glycol in vivo, and the Mitochondrial Dynamics of Toxic Metabolite Diglycolic Acid in vitro
Corie Robinson, (PhD, 2018), currently working as Study Director of Toxicology at Covance Laboratories.
Dissertation: Analyzing the transport and kinetic mechanisms of diglycolic acid as the underlying cause of diethylene glycol toxicity
Ike Muslow Predoctoral Fellowship from LSU Health Shreveport, 2015-17
American Academy of Clinical Toxicology Student and Trainee NACCT Travel Award, 2015
Society of Toxicology Domestic ToxScholar, 2016
Elliot Luttrell-Williams, (MS, 2017), currently working as a Research Assistant at NYU Langone
Taylor Conrad, (MD, 2016), LSU Health Shreveport Medical Student research internship (2013-2016), now is Resident Physician at Kings County Hospital Center, Brooklyn New York
AOA 2015 Carolyn L. Kuckein Student Research Fellowship
Cody Dunning, Undergraduate Student Assistant (2011-2015), now enrolled in Southern University at Shreveport School of Nursing
Kiera Broussard, Undergraduate Student Research Internship (2015), now is undergraduate student at Xavier University
Royce Nichols, Undergraduate Student Research Internship (2014), now is Graduate Student, Mississippi State University
Greg Landry, (PhD, 2013), now is Assistant Professor, Department of Pharmacology & Toxicology, Massachusetts College of Pharmacy and Health Sciences.
Ike Muslow Predoctoral Fellowship from LSU Health Shreveport, 2011-13
AstraZeneca Pharmaceuticals Graduate Student Fellowship, 2011-13
Informa Innovative Research Abstract Award at the North American Congress of Clinical Toxicology, 2012
Society of Toxicology Renal Toxicology Award, 2013
Finalist (top 6) for Carl C. Smith Award, Society of Toxicology Mechanisms Specialty Section, 2012
Finalist (top 6) for Carl C. Smith Award, Society of Toxicology Mechanisms Specialty Section, 2013
Lauren Besenhofer, (PhD, 2011), now is Staff toxicologist at Abbvie, Inc
Finalist (top 12) for Carl C. Smith Award, Society of Toxicology Mechanisms Specialty Section, 2011
Yan Li, (PhD, 2010), now is Postdoctoral Fellow at LSU Health Shreveport, Department of Pathology
Finalist (top 12) for Carl C. Smith Award, Society of Toxicology Mechanisms Specialty Section, 2009
Travel Award, National Institute of Diabetes and Digestive and Kidney Diseases for the meeting: Anion Transporters and Oxalate Homeostasis: From Genes to Diseases, 2008
Mallory Hitt Allen, (MD, 2015), LSU medical student research internship (2012), Resident physician at Children's Hospital of The King's Daughters, Norfolk VA
Courtney Jamison, Undergraduate Student Research Internship (2013), now is Graduate student, LSU Health Shreveport
Tess Dupree, Undergraduate Student Research Internship (2012), now is Graduate student, University of Louisville
Corie Robinson, Undergraduate Student Research Internship (2011), now is Graduate student, LSU Health Shreveport
Sarah Martin, PhD, Undergraduate Student Research Internship (2009), now is Postdoctoral Researcher at UT Southwestern Medical Center, Dallas
POSITIONS
Post-doctoral Fellows
While we are not currently recruiting Post-doctoral Fellows, quality candidates will always be considered. To inquire about opportunities, contact Dr. McMartin at kenneth.mcmartin@lsuhs.edu.
Graduate Students
For information about our Ph.D. and M.S. programs, please contact Ty Martinez at Tmoren@lsuhsc.edu. For information about research conducted in the McMartin Lab, please contact Dr. McMartin at kenneth.mcmartin@lsuhs.edu.
Undergraduate Research Assistants
The McMartin Lab maintains an active program for undergraduate research interns, during the school year as well as the summer. Please email kenneth.mcmartin@lsuhs.edu.
Medical Students, Residents, and Fellows
The McMartin Lab has a number of research projects available for any Medical Students, Residents, and Fellows interested in performing toxicology research.
Contact
Contact Us
LSU Health Shreveport
Department of Pharmacology, Toxicology and Neuroscience
1501 Kings Hwy
Shreveport, LA 71103
Email:
kenneth.mcmartin@lsuhs.edu
Office:
(318) 675-7871
McMartin Lab
McMartin Lab
